Vaughan Magazine

Maintaining user group lists is a pain. Often users cobble together
their own utilities to help the process, but maintaining those things
is a pain, too.

Imanami has a nice set of tools that reduce the burden on Exchange admins:

DTM
provides synchronization with various repositories. Eg Active
Directory, Peoplesoft, SunOne/iPlanet, Oracle, SAP, DB2, LDAP, CSV
files, SQL, Excel, Access

SmartDL automates the creation and maintenance of Exchange and Active Directory distribution lists and security groups

WebDir lets users update their own directory information

… David Ferris

David Byrne on bicycling in NYC•••Published June 18, 2007 at Journal.DavidByrne.com
By David Byrne I have been riding a bicycle in New York City for almost 30 years! For transport, not for sport. At first there were only a few of us. Loners, losers, maniacs and nerds. Some of the members of Talking Heads used to make fun of me and say I was going to turn into Pee Wee Herman — and they weren’t talking about his extensive porno collection. But we knew some pleasures of which other New Yorkers seemed completely ignorant. Pleasures available to all. An exhilarating feeling as the air rushes past and we dodge taxis and New York pedestrians, who still insist on playing in the traffic. A feeling of flying through and around the inevitably stalled traffic. One has to stay alert — if your attention wavers, you’re done for. Who needs coffee? Or a morning at the gym? A ride across town gets the adrenalin going as one heads to work or to the studio in the morning. By the time one arrives for a meeting one is fully awake — blood pumping, on alert — having often just had 3 near-death experiences. In the hot New York summers, yes, one can tend to “glisten” when one arrives at an appointment, which is not always appreciated, so I had a shower installed in my office. But, if one pedals at a relaxed pace and stays away from the snarled traffic as much as possible (cars and trucks raise the surrounding temperature) one can arrive more or less dry, but with a healthy glow.
Over the decades things have improved in New York for cyclists — a little. Now there is a wonderful bike path up the Hudson that runs almost the entire length of Manhattan. I use it to commute to and from work. Now there are markings on some streets indicating imaginary bike lanes (imaginary because the traffic and pedestrians often ignore the markings) but they are there in spirit, at least. Someday they will be taken seriously, I have no doubt — when gas hits $10 a gallon. Now Paris is embarking on a bicycle plan that should make New York envious. A collaboration between business and civic affairs than may just work, as both the city and Deceaux can benefit. Bikes as a means of local transport has worked elsewhere; the mayor of Bogota, Enrique Pe

It's in the shoes: Blair reveals
France24 - Paris,France
Outgoing British Prime Minister Tony Blair revealed Friday that he had worn
the same pair of shoes to his weekly question-and-answer session in
parliament …
<http://www.france24.com/france24Public/en/administration/afp-news.html?id=070621225556.70qd3pkh&cat=null>
Blair puts his success down to 'lucky shoes'
New Zealand Herald - New Zealand
Tony Blair puts his success at Prime Minister's Questions down to his lucky
leather shoes. Photo / Reuters Outgoing British Prime Minister Tony Blair
…
<http://www.nzherald.co.nz/section/6/story.cfm?c_id=6&objectid=10447269>
Shoes make women's hearts flutter
This Is Basingstoke - Basingstoke,UK
IT MAY be just confirming what many already suspected, but a new study has
shown that a great pair of shoes sets the pulses of Basingstoke women
racing. …
<http://www.thisisbasingstoke.co.uk/display.var.1488421.0.shoes_make_womens_hearts_flutter.php>
Blair wears same shoes for 10 years
ABC Online - Australia
Outgoing British Prime Minister Tony Blair has revealed he has worn the
same pair of shoes to his weekly question-and-answer session in Parliament
since …
<http://www.abc.net.au/news/stories/2007/06/22/1958797.htm>
Wholesale Shoes Site Add Hundreds of New Footwear Products
PR Web (press release) - Ferndale,WA,USA
Site for wholesale shoes, DealADayShoes.com, adds hundreds of new shoes
styles for wholesale shoe buyers. New York, NY (PRWEB) June 21, …
<http://www.prweb.com/releases/2007/6/prweb535064.htm>
GRAY MATTER: Rosie can't fill Barker's shoes
West Salem Coulee News - West Salem,WI,USA
By TIM GRAY The pop culture icon's retirement from the Price is Right
marked the end of a daytime television dynasty. Who's going to remind us
to get our …
<http://www.couleenews.com/articles/2007/06/21/opinion/01gray.txt>
Big Shoes for 2008 H'wood Walk of Fame
Forbes - NY,USA
AP 06.21.07, 3:54 PM ET Ricky Martin, Brooks & Dunn, Tim Robbins, Cate
Blanchett, Angela Bassett, Howie Mandel and the late George Harrison are
among the …
<http://www.forbes.com/feeds/ap/2007/06/21/ap3845878.html>
Big Shoes for 2008 H'wood Walk of Fame
News Channel 7 - SC,USA
AP Photo/Santiago LLanquin LOS ANGELES (AP) — Ricky Martin, Brooks & Dunn,
Tim Robbins, Cate Blanchett, Angela Bassett, Howie Mandel and the late
George …
<http://hosted.ap.org/dynamic/stories/P/PEOPLE_WALK_OF_FAME?SITE=WSPATV&SECTION=NATIONAL&TEMPLATE=DEFAULT&CTIME=2007-06-21-15-54-31>
Pepe shoes
Babygadget - Kensington,MD,USA
I've been meaning to write about Pepe shoes for a while, but their website
has forever been "a work in progress." I guess they have better things to
do, …
<http://www.babygadget.net/2007/06/pepe_shoes.php>
Landing looking for shoes
Branson Daily News - MO, United States
By Brandon Cone More children in the Tri-Lakes Area will hopefully be
wearing new shoes to school this coming school year thanks to the efforts
of several …
<http://www.bransondailynews.com/story.php?storyID=4080>
Korean Rubber Shoes Redesigned
Ping Mag's Korean Rubber Shoes Redesigned, which is much more interesting than it first sounds.
<http://coudal.com/archives/2007/06/korean_rubber_s.php>
Coudal Partners Blended Feed
<http://www.coudal.com/>Banana Republic Summer Sale
By Sally Green(Sally Green)
… and save up to 50% on selected women, petites and women's tall clothing, denim, intimates, swimwear, jewelry, shoes and handbags, as well as men's shirts, polos & tees, sweaters, blazers & outerwear, pants, shoes and accessories. …
<http://www.chicalert.com/2007/06/banana-republic-summer-sale.html>
Chic Alert: Designer Clothing,…
<http://www.chicalert.com/>Hiking Sandals: The Perfect Travel Shoes
By Laura Moncur
Normally I would have worn running shoes on a trip such as our visit to Cambodia. That's what I have always done in the past. But when I was in South Africa last year, I saw this couple wearing hiking sandals (matching colors, to boot), …
<http://www.starling-travel.com/2007/06/21/hiking-sandals-the-perfect-travel-shoes/>
Starling Travel
<http://www.starling-travel.com>Save the planet: clean your shoes with bananas?
By Alister Doyle
In an online survey, the banana shoe tip was the most popular (…though I guess not necessarily the one most used) - "To clean leather shoes, rub with banana peel (the inside of the peel), then wipe and buff with a cloth". …
<http://blogs.reuters.com/2007/06/21/save-the-planet-clean-your-shoes-with-bananas/>
Reuters Blogs
<http://blogs.reuters.com>Disgusting shoes, but I love them
By robbbiedobbbie(robbbiedobbbie)
Shoes don't do well with me - I'm not LIGHT, and I have dizzingly high arches, so the sides of shoes collapse early. Anyway, I'm working on embracing my inner floopiness (thanks for the sartorial inspiration, LOSTDWARF! …
<http://robbbiedobbbie.vox.com/library/post/disgusting-shoes-but-i-love-them.html>
robbbiedobbbieday
<http://robbbiedobbbie.vox.com/library/posts/page/1/>

Today was maintenance day for the Belmont in Africa group. We went to the Living Home Community Centre and worked for four hours helping to clean up construction debris along a fence row. That simple description fails to capture the fine efforts of the whole team today.
Everyone worked without complaint and cooperatively until the last brick was stacked and the last fence post pulled.

We have spent a lot of time with children the last three days and they have been a simple delight. Today, we were with ourselves, the South African sun, bricks, pipes, rocks, metal beams, and wire, lots of wire. Our task was to clear debris away from a new fence row to enable the Living Hope gardener to plant shrubbery and flowers. When we arrived, Des, the maintenance supervisor for Living Hope showed us the debris and the pile of bricks and thanked us for our willingness to help in their work.

It was hard work and not nearly as rewarding at the immediate feedback that comes from working with children. There were no hugs, no laughter from smiling children, and no songs in Afrikaans. We could hear the chatter of the group stacking bricks, the swish of spade being pushed into sandy soil, the grunts of digging up stumps and poles, and the low conversation of work. Twice the students filled up the bed of a pickup truck with large stones they had unearthed. Six former fence poles with 150+ pounds of cement were pulled out of their holes. Metal beams and pipe and wiring were dug up and stacked neatly on the back of the property. The team working with bricks patiently moved 3,866 bricks from a huge tumbled pile and turned them into a neat and orderly stack.

At the end of the day, we talked about how the twenty-two of us (Dr. Overby missed all the fun by choosing the day to visiting another university partner) had worked for a total of eighty-eight hours–basically we had done the work that it would have taken one person to do in two weeks . . . in just four hours. As a non-profit organization, attempting to use every dollar (or Rand) to change lives, Living Hope exists on volunteer labor. The money we saved will go directly into making some else’s life healthier and better.

Furthermore we learned, that the Living Hope building sits in such a way that one side with a porch gets wind at one time of the year and the other side with a porch gets wind the opposite time of the year. We were working on the side that gets wind this time of year. The plan is to get new shubbery in now, let it get rooted and grown, so when the wind blows on the other side of the building later in the year, the patients can move to the side of the building where we worked today. By then, what was once construction debris and unsightly piles of trash, will now be beautiful shrubs and flowers. It is not much, but when your health is poor and you are fighting for your life, a beautiful sunset, some greenery, and some flowers can do a lot to make you feel better. While we will not be there when it happens, some time next year a patient will sit on that porch and enjoy the view and feel just a little bit better. It will make every spade of dirt we shoveled, every metal pipe we moved, and every brick we stacked worthwhile. There are lots of ways and reasons to help others.

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Ice Cube (born O’Shea Jackson on June 15, 1969) is an American rapper, actor and film director. Regarded as one of the greatest hip hop artists,[1][2] he began his career as a founding member of the famously controversial rap group N.W.A., and later launched a successful solo career in music and cinema. In 1992 he married Kim Jackson, with whom he has four children [3]. Later in 1992, he converted to Islam[4]. From the mid-90s onwards, Cube focused on acting, and his musical output has slowed down considerably. He remains one of the most visible West Coast rappers, having helped originate gangsta rap. He is particularly well-known for his incendiary raps on political and racial topics (such as the treatment of blacks in the United States). He has sold 13.5 million units in the U.S. alone and is one of the richest people in the hip hop industry, having an estimated net worth of $145 million (According to[1] he was #7 in their “Top Ten Richest People in Hip Hop 2006″).

Biography
Early life
Cube was born to Doris Benjamin, a hospital clerk, and Andrew Jackson, a machinist and groundskeeper, both both of whom came from the South. He was raised in South Central Los Angeles and later converted to Islam during the early 1990s.[5] At sixteen, he developed an interest in hip hop music, and began writing raps while attending school at Taft High School (Los Angeles). He attended the Phoenix Institute of Technology in the fall of 1987, and studied Architectural Drafting. With friend, Sir Jinx, Cube formed the group, C.I.A., and they performed at parties hosted by then-DJ and World Class Wreckin Cru member, Dr.Dre. In his earliest stages of rapping, he had his cousin, Del tha Funkee Homosapien, ghost write for him. While the exact number of rhymes Del wrote for N.W.A. is uncertain, it is known that he wrote or contributed on at least twenty of the group’s tracks.

1987-1990: N.W.A. era
In 1987 Cube and Dr. Dre released the EP My Posse, under the alias CIA. After the collaboration, Cube showed Eazy-E, the lyrics to “Boyz-N-The-Hood.” Eazy-E eventually recorded the song, which debuted on N.W.A. and the Posse, the debut N.W.A. album.

By this point Cube was a full-time member of N.W.A. along with Dr.Dre and (to a lesser extent) MC Ren. Cube wrote Dr. Dre and Eazy-E’s rhymes for the group’s landmark album, Straight Outta Compton, released in 1989. However, as 1990 approached, Cube found himself at odds with the group’s manager, Jerry Heller, after Heller responded to the group’s financial questions by drafting up a new arrangement. As he explains in the book Ice Cube: Attitude (McIver, 2002) ISBN 1860744281:

Heller gave me this contract, and I said I wanted a lawyer to see it. He almost fell out of his chair. I guess he figure, how this young muthafucka turn down all this money? [$75,000] Everybody else signed. I told them I wanted to make sure my shit was right first.
Since Cube wrote the lyrics to approximately half of both Straight Outta Compton, and Eazy-E’s solo album, Eazy-Duz-It, Cube was advised of the amounts he was truly owed by Heller, and proceeded to take legal action, soon after leaving the group. In response, the remaining N.W.A. members attacked Cube on the EP 100 Miles and Runnin’, as well as their next and final album, Efil4zaggin.

Solo career
Cube recorded his debut solo album in New York City, with his group Da Lench Mob, and the Bomb Squad (Public Enemy’s production team). AmeriKKKa’s Most Wanted was released in 1990 and was an instant hit, riding and contributing to the rising tide of rap’s popularity in mainstream society. The album was charged with controversy, and Cube was accused of misogyny, and anti-white racism.

Cube subsequently appointed the female rapper Yo-Yo (who appeared on AmeriKKKa’s Most Wanted) to the head of his own record label and helped produce her debut album, Make Way for the Motherlode. This was followed by a critically acclaimed role as ‘Doughboy’ in John Singleton’s hood-based drama, Boyz N the Hood. The film began the rapper’s increasing tendency to star in action movies as time went on.

In the same year as AmeriKKKa’s Most Wanted, Cube released the highly acclaimed EP, Kill At Will. Kill At Will soon became a hit becoming the first Hip Hop EP to go both Gold and Platinum, and many praise it as being his best work.

Cube’s 1991 follow-up, Death Certificate was regarded as more focused, yet even more controversial, and critics accused him again of being anti-white, anti-female, anti-Semitic and homophobic. The album is thematically divided into the ‘Death Side’ (”a vision of where we are today”) and the ‘Life Side’ (”a vision of where we need to go”). The album also features a scathing response to N.W.A., called “No Vaseline”. It also contained the track “Black Korea”, regarded by some as prophetic of the L.A. riots, but also interpreted as racist by others; it was still being cited years after its release.[6] Cube toured with Lollapalooza in 1992, which widened his fan base [7]. Also during that year, he converted to Islam, though he denied any affiliation with the organization of Nation of Islam [8].

Cube released The Predator in November 1992, which had been recorded amidst the LA uprising of ‘92. Referring specifically to the riots, in the first single, “Wicked”, Cube rapped “April 29 was power to the people and we might just see a sequel.” The Predator debuted at #1 on both the pop and R&B charts, the first album in history to do so. Singles from The Predator included “It Was a Good Day” and the “Check Yo Self” remix, and the songs had a two part music video. The album remains Cube’s the most successful release, with over 3 million copies sold in the US. However, after The Predator, Cube’s rap audience slowly began to diminish. Lethal Injection which was released in the end of 1993 and represented Cube’s first attempt at imitating the G-Funk sound of Dr. Dre’s The Chronic, wasn’t well received by critics, though fans have come to cite it as some of his best works. He had more successful hits from Lethal Injection, including “Really Doe”, “Bop Gun (One Nation)”, “You Know How We Do It” & “What Can I Do?”. Following the busy year of 1994, he took a hiatus from music and concentrated on film work and developing the careers of other rap musicians, such as Mack 10, and Mr. Short Khop.

In 1998, Cube released his long-awaited solo album, War & Peace Volume 1. The delayed second part, War & Peace Volume 2, was released in 2000. The albums featured appearances from Westside Connection as well as a reunion with fellow N.W.A. members, Dr. Dre & MC Ren, though many fans maintained that the two albums weren’t on par with his past work, especially the second volume.

In 2006, Ice Cube released his 8th solo album, Laugh Now, Cry Later, on his Da Lench Mob Records label, debuting at #4 on the Billboard Charts and selling 144,000 units in the first week.[9] The album featured production from Lil Jon and Scott Storch, who produced the lead single “Why We Thugs”. In 2007 he’s set to release his 9th studio album titlted Raw Footage.

Westside Connection
In 1994, Cube formed Westside Connection with Mack 10, and WC, and together they released an album called Bow Down. Most of the album was used to engage in the war of words between the East and West Coasts of the 90s. The album’s eponymous single reached #21 on the singles charts, and the album itself was certified Platinum by the end of 1996.

With Bow Down, Westside Connection brought their own agenda to the hip hop scene. Ice Cube, Mack 10, and WC had grown tired of being overlooked by most East Coast media outlets; the album was designed to instill a sense of pride in West Coast rap fans and to start a larger movement that anyone who felt underappreciated might identify with. Songs like “Bow Down” and “Gangstas Make the World Go ‘Round” make reference to this.

After a seven-year hiatus, Westside Connection returned with their second effort Terrorist Threats in 2003. The album fared well critically, but its commercial reception was less than that of Bow Down. “Gangsta Nation” was the only single released from the album, which featured Nate Dogg and was a radio hit. After a rift occurred between Cube and Mack 10, regarding Cube’s commitments to film work rather than touring with the group, Westside Connection disbanded. WC, however is still friends with Ice Cube and is planning a new solo album on Lench Mob Records entitled Guilty by Affiliation in late 2006.

Collaborations & film work
In 1992, while taking a break from his own output, Cube assisted on debut albums from Da Lench Mob (Guerillas In Tha Mist, 1992) and Kam (Neva Again, 1993), both of which enjoyed critical acclaim and some moderate commercial success. He handled most of the production on ‘Guerillas in tha Mist.

In 1993, Lench Mob member, J-Dee, was sentenced to life imprisonment for attempted murder, and Cube did not produce their next album, Planet of tha Apes. Around this time in 1993, Cube also worked with Tupac Shakur on his album Strictly 4 My N.I.G.G.A.Z., appearing on the track “Last Words” with Ice-T. He also did a song with Dr. Dre for the first time since he left N.W.A.: “Natural Born Killaz”, for the Murder Was The Case soundtrack. Cube appeared on the song “Children Of The Korn” by rock group Korn, and lent his voice to British DJ Paul Oakenfold’s solo debut album, Bunkka, on the track “Get Em Up”.

Following, perhaps his most famous film role, as ‘Doughboy’ in Boyz N the Hood, in 1992 he starred alongside Ice-T, and Bill Paxton in Walter Hill’s action film, Trespass, and then in The Glass Shield.

In 1995, Cube had some breakthrough film roles, first in the hit comedy Friday starring alongside then-upcoming comedian Chris Tucker, which spawned two sequels: Next Friday and Friday After Next.

That year he also starred in his second collaboration with John Singleton, Higher Learning, as world-weary university student, “Fudge”; a role for which he earned award nominations.

He had a supporting role in 1997’s Anaconda. He wrote, executive produced, and made his directorial debut in The Players Club in 1998, and in 1999, starred alongside George Clooney and Mark Wahlberg in the critically acclaimed Three Kings. In 2002, Ice Cube starred in the commercially successful movie Barbershop, as well as its 2004 sequel Barbershop 2: Back in Business. In early 2005, Ice Cube came back to Hollywood and starred with Samuel L. Jackson in the action movie XXX: State of the Union and then alongside Nia Long in the family comedy, Are We There Yet?.

In early April 2007 Ice Cube was a guest on Angie Martinez’ Hot97 radio show and stated that he was interested in bringing back Chris Tucker as ‘Smokey’ in a possible Friday sequel, but that was only possible if “New Line cuts the check.”[10]. This is unlikely as Tucker’s Rush Hour sequel performances earned him over 20 million dollars per film, and the entire budget for the sequel “Next Friday” was only 11 million dollars [11]. To date, no Friday sequel is officially in the works beyond concept development, and Tucker himself has publicly never indicated any interest in appearing in a Friday sequel over the last 12 years.

Recent years
In 2004, his hit singles “Check Yo Self”, “It Was a Good Day” and affiliated song “Guerillas In Tha Mist” with Da Lench Mob appeared on popular videogame Grand Theft Auto: San Andreas, playing on fictional radio station Radio Los Santos.

In late 2005, Ice Cube and Emmy Award winning filmmaker R.J. Cutler, teamed up to create the six-part documentary series titled Black. White., which was broadcast on cable network FX. Cube’s upcoming movie projects include “The Extractors” and “Teacher of the Year” scheduled to be released in 2006. Cube has also begun production on Are We Done Yet?, the sequel to 2005s “Are We There Yet?”.[12]

Ice Cube has been working with Eazy-E’s son, Lil Eazy-E, on his debut album due in 2007, entitled Prince of Compton. He has also signed on to star in and produce Welcome Back, Kotter, a big screen adaptation of the ’70s television series.[13] Cube will play the title character, who was originally portrayed by Gabe Kaplan. Cube’s film company, Cube Vision Productions, has sealed a deal with Dimension Films to bring the show to the big screen.

In an interview in London, he revealed he is in talks of a collaboration with Gorillaz after speaking to frontman Damon Albarn.[14] He will be featured on Bone Thugs-N-Harmony’s upcoming album Strength and Loyalty.

Conflicts and rivalries
Accusations of racism
In 1991, Ice Cube released the song, “Black Korea,” which attacks Korean store owners who were deemed “racist” in their attitudes toward blacks, suspecting the blacks of violent and criminal proclivities. One year later, in 1992, the Los Angeles riots took place, in which over $1b of damage was caused, largely by black looters, and with over 50% of the damages incurred by Korean businesses.

Feuds
Common
Cube also had problems with Chicago MC Common, over the rapper’s 1994 single “I Used to Love H.E.R.”. In the song about the degradation of hip hop, Common made references to the West Coast and Boyz N the Hood. With his Westside Connection cohorts, Mack 10 and WC, Cube recorded the song “Westside Slaughterhouse”, which coincidently was their first track together. The song contained the following lines directed at Common:

Used to love her, mad cause we fucked her
Pussy whipped bitch with no common sense
Hip hop started in the west,
Ice Cube ballin’ thru the East Without A Vest
Common responded with “The Bitch in Yoo”, retorting “You ain’t made shit dope since AmeriKKKa’s Most”. Afterward Louis Farrakhan called the two to a sit-down to negotiate a truce.

Cypress Hill
L.A. group Cypress Hill also had a feud with Ice Cube when they felt that Ice Cube had taken the chorus from the song “Throw Your Set in the Air” for the song “Friday”. Cypress Hill released a diss track entitled “No Rest For the Wicked”, which among other things, took shots at Ice Cube for using pictures of an ornate marijuana pipe that had belonged to DJ Muggs for the cover of his album The Predator despite not smoking marijuana at that time. Ice Cube and the Westside Connection retaliated with “King of the Hill”, & ” Cross Em Out & Put a K”, to which Cypress Hill responded with “Ice Cube Killa”. In 1997 B-Real of Cypress Hill and Ice Cube were invited to a late night talk show in order to reconcile their differences for the benefit of the hip hop community, and the feud thus ended. Cube And B-Real would work together later that year as guest features on the track “Men of Steel” for the soundtrack of Shaquille O’Neal’s film Steel.

Kam
Ice Cube had a falling out with Kam due to money and personal issues, which led to Kam releasing the venomous diss track “Whoop Whoop”, as well as an altercation that led to the theft of Ice Cube’s necklace. Though the feud has since ended, they never worked together again.

Oprah Winfrey
In May 2006 Ice Cube accused Oprah Winfrey of not welcoming rappers on her show, and specifically, for not inviting him to the show when the rest of the cast of the hit show Black. White. were invited.[

Rapping
Technique
Cube’s rap technique is often straightforward, without the use of many similes. He is known for the social commentary in his songs, and implies that he just reports things how he sees them, though some critics accuse him of racism for epithets such as “caveman” and “devil”. His solo style never differed from his N.W.A. days, using defensive and offensive violence or simply bragging, narratives and political hip hop like several popular East Coast acts of the time.

Whilst his technique is often straightforward in terms of avoiding similies, he actually uses metaphor to a huge extent in his songs. This has been prevalent since the early days of his solo career, and really came to fruition during Death Certificate. Ice Cube’s lyrics and themes are rich with metaphor.

His work would later inspire artists such as Nas to voice one’s aspects and views on society. Ice Cube is known for the use of irony, as he does in “It Was a Good Day”, when he details a day that was good because nobody was shot or sent to jail. He uses this as a commentary on life in the ghetto (where people are often shot or sent to jail). He also became a well-known battle MC, going for his opponents’ credibility, and pioneered the tactic of dissing a rival over their own beat, with the song “Jackin’ for Beats” from the 1990 EP, Kill At Will.

Subject matter
His first album, AmeriKKKa’s Most Wanted, deals with straightforward topics such as poverty, racism and drug abuse in the ghetto. In order for the listener to easily relate, Cube would often use first person narration, as he does in the song “Once Upon A Time In The Projects”, where he is arrested for being in the wrong place at the wrong time. His style has shown to influence the early work of both Tupac and The Notorious B.I.G.

Death Certificate was deemed angrier and very controversial, which led to some US states banning it for derisive remarks toward white people and Koreans; he also comments on the hypocrisy of some leaders in the USA and says of Uncle Sam, “I wanna kill Sam ’cause he ain’t my motherfuckin’ uncle.” His subsequent albums have been slightly less aggressive in their approach, such as War & Peace - Volume 2 (The Peace Disc), which focuses on ways to remedy issues such as poverty and violence. Also, on War & Peace - Volume 1 (The War Disc), he collaborated with the rock band, KoRn. On his latest album, Laugh Now, Cry Later, he speaks out against the Iraq War, and makes less than favorable comparisons between George W. Bush and Saddam Hussein.

Music awards
VH1 Hip Hop Honors 2006
2006 Honoree
2005 Soul Train Music Awards
Lifetime Achievement Award
2000 Hip Hop Music Awards
Lifetime Achievement Award (with Dr. Dre)

Filmography

Actor
Boyz N the Hood (1991) as “Doughboy” Darin Elvidge
Trespass (1992) as Savon
CB4 (1993) as himself in segment
The Glass Shield (1994) as Teddy Woods
Higher Learning (1995) as Fudge
Friday (1995) as Craig
Dangerous Ground (1997) as Vusi Madlazi
Anaconda (1997) as Danny Rich
The Players Club (1998) as Reggie
I Got the Hook Up (1998) as Gun Runner
Three Kings (1999) as SSgt. Chief Elgin
Thicker Than Water (1999) as Slink
Next Friday (2000) as Craig
Ghosts of Mars (2001) as James ‘Desolation’ Williams
All About the Benjamins (2002) as Bookum
BarberShop (2002) as Calvin Palmer
Friday After Next (2002) as Craig
Torque (2004) as Trey
BarberShop 2: Back in Business (2004) as Calvin
Are We There Yet? (2005) as Nick Persons
xXx: State of the Union (2005) as Darius Stone
Are We Done Yet? (2007) as Nick Persons
The Extractors (2008)
First Sunday (2008)

Director/Writer/Producer filmography
Friday (1995) Writer, Executive Producer
Dangerous Ground (1997) Executive Producer
The Players Club (1998) Writer, Director, Executive Producer,
Next Friday (2000) Writer, Producer
All About The Benjamins (2002) Producer
Friday After Next (2002) Writer, Producer
BarberShop 2: Back in Business (2004) Executive Producer
BarberShop: The Series (2005) Executive Producer
Are We There Yet? (2005) Producer
Beauty Shop (2005) Executive Producer
Black. White. (2006) Executive Producer
Are We Done Yet? (2007) Producer

Wednesday, April 04, 2007

INVITED LECTURE – 6 (Co-Chairs: Lowrie Powell, Hisao Hayashi)

08:30 am - 09:00 am
IL-11: The Pathogenesis of Porphyria Cutanea Tarda
James Kushner, MD

09:00 am - 09:30 am
IL-12: Fibrosis
Grant A. Ramm, BSc, PhD

INVITED LECTURE – 7 (Co-Chairs: Robert Fleming, Pensri Pootrakul)

09:30 am - 10:00 am
IL-13: Secondary Iron Overload and ICL670
Antonio Piga, M.D.

10:00 am - 10:30 am
IIL-14: QUANTITATIVE IMAGING OF HUMAN LIVER IRON CONCENTRATIONS IN VIVO
T. St. Pierre, PhD, A. Fleming, BSc, W. Chua-anusorn, PhD, P. Clark, PhD, E. Rossi, PhD, G. Jeffrey, MD/PhD and J. Olynyk, MD/PhD, The University of Western Australia (Presented By: T. St. Pierre, PhD)

10:30 am - 11:00 am
Break

01:30 pm - 04:10 pm
NOVARTIS SYMPOSIUM: IRON LOADING AND ITS CLINICAL IMPLICATIONS (Co-Chairs: Antonello Pietrangelo, Chaim Hershko)

PLENARY SESSION – 1 (Co-Chairs: Paulo Arosio, Fumio Kishi)

11:00 am - 11:20 am
PL-01: GROWTH DIFFERENTIATION FACTOR 15 IS PRODUCED AT HIGH LEVELS IN PATIENTS WITH BETA THALASSEMIA AND INHIBITS HEPCIDIN EXPRESSION IN PRIMARY
T. Tanno, DVM, PhD, N. Bhanu, PhD, P. Oneal, MD, S. Goh, PhD, P. Staker, T. Lee, R. Childs, MD, S. Leitman, MD, N. Luban, MD and J. Miller, MD, Molecular Medicine Branch/ NIDDK/ NIH (Presented By: T. Tanno, DVM, PhD)

11:20 am - 11:40 am
PL-02: AN ADVANCED IRON-METABOLISM MICROCHIP FOR LARGE SCALE POPULATION SCREENING OF MUTATIONS AND POLYMORPHISMS IN GENES INVOLVED IN IRON METABOLISM
L. Cremonesi, PhD, S. Bonalumi, F. Ferrari, A. Brisci, N. Soriani, B. Foglieni, C. Camaschella, M.Cazzola, G. Biasiotto, P. Arosio and M. Ferrari, Genomic Unit for the Diagnosis of Human Pathologies, (Presented By: L. Cremonesi, PhD)

11:40 am - 12:00 pm
PL-03: METAL DISTRIBUTION AND GENE EXPRESSION PROFILE IN DMT1 KNOCKOUT MICE
H. Gunshin, PhD, C. Tohyama, PhD, Y. Vainshtein, PhD, M. Hentze, MD, M. Muckenthaler, PhD and N. Andrews, MD, PhD, University of Massachusetts (Presented By: H. Gunshin, PhD)

11:00 am - 12:00 pm
Concurrent Session 5: No, Oxygen, HO, Oxydative Stress (Co-Chairs: Roberta Ward, Yuzou Nishida)
Location: Hall II (Room C-1)

11:00 am
O-21: NITRIC OXIDE (NO+) ENHANCES FERRITIN SYNTHESIS BY BOTH IRP-DEPENDENT AND -INDEPENDENT MECHANISMS
M. Mikhael, BSc, S. Kim, BSc, MSc, PhD, M. Schranzhofer, BSc, MSc, PhD, S. Soe-Lin, BSc, A. Sheftel, BSc, PhD, E. Mullner, BSc, MSc, PhD and P. Ponka, BSc, MD, PhD, Lady Davis Institute, Rm 202 (Presented By: M. Mikhael, BSc)

11:15 am
O-22: CROSSTALK BETWEEN OXYGEN AND IRON METABOLISM: IRON-REGULATORY PROTEINS LIMIT HYPOXIA INDUCIBLE FACTOR 2 ALPHA EXPRESSION IN IRON DEFICIENCY
M. Sanchez, PhD, B. Galy, PhD, M. Muckenthaler, Prof, PhD and M. Hentze, Prof, PhD, European Molecular Biology Laboratory (EMBL) (Presented By: M. Sanchez, PhD)

11:30 am
O-23: THE IRON STORAGE FUNCTION OF FERRITIN H PROTECTS CELLS FROM IRON TOXICITY BY OXIDATIVE DAMAGE
L.C. Kühn, L. Richman, D. Darshan, Swiss Institute for Experimental Cancer Research (ISREC), Epalinges, Switzerland

11:45 am
O-24: TRANSGENIC OVEREXPRESSION OF HEME OXYGENASE-1 INDUCES IRON AND PORPHYRIN ACCUMULATION IN MICE
L. Zhou, MsSci, X. Gao, PhD, Y. Togashi, BachelorSci, M. Satoh, PhD, M. Yamamota, PhD, T. Yoshida, PhD and O. Nakajima, PhD, Research Laboratory for Molecular Genetics, Yamagata University (Presented By: L. Zhou, MsSci)

11:00 am - 12:00 pm
Concurrent Session 6: Cancer (Co-Chairs: Des Richardson, Junji Kato)
Location: Hall III (Room C-2)

11:00 am
O-35: REDUCTION OF HEPATIC 8-OH-DG LEVELS AND HISTOLOGICAL IMPROVEMENT IN NON-ALCOHOLIC STEATOHEPATITIS PATIENTS UNDERGOING IRON DEPLETION THERAPY BY PHLEBOTOMY AND LOW IRON DIET
K. Takada, J. Kato, Y. Kawano, M. Kobune, R. Takimoto, S. Takahashi, K. Takanashi, K. Miyanishi and Y. Niitsu, Sapporo Med Univ Sch Med, 4th Dept Int Med (Presented By: K. Takada)

11:15 am
O-36: HEPATIC IRON OVERLOAD IN A WILSON DISEASE MODEL OF LONG-EVANS CINNAMON RATS
H. Hayashi, MD, M. Yano, MD, S. Wakusawa, PhD, Y. Fujita, BS, K. Hayashi, MD, Y. Katano, MD and H. Goto, MD, Aichi Gakuin University School of Pharmacy (Presented By: H. Hayashi, MD)

11:30 am
O-37: A MODULATION OF IRON TRANSPORT PROTEINS IN OESOPHAGEAL ADENOCARCINOMA
C. Tselepis, Bsc PhD, M. Brookes, MBChB, MRCP, J. Boult, BMedSci, K. Roberts, MBChB, G. Anderson, PhD, R. Spychal, MD, FRCS and T. Iqbal, MD, FRCP, University of Birmingham (Presented By: C. Tselepis, Bsc PhD)

11:45 am
O-38: EXPRESSION OF HCP-1 IN OESOPHAGEAL CARCINOGENESIS
T. Iqbal, M. Brookes, MBChB, K. Roberts, MBChB, J. Boult, BMedSci, A. McKie, PhD, R. Spychal, MD and C. Tselepis, PhD, CRUK Institute for Cancer Studies (Presented By: T. Iqbal)

12:00 pm - 01:30 pm
Lunch

01:30 pm - 04:00 pm
Presidential Symposium: New Approaches to Therapy for Iron-Related Disease(Co-Chairs: Jerry Kaplan, Piere Brissot)

01:30 pm - 01:45 pm
Introduction
Pierre Brissot

01:45 pm - 02:00 pm
PS-01: SALMONELLA TYPHIMURIUM INFECTION AND IRON METABOLISM IN MICE PRESENTING CONSTITUTIVE HEMOLYTIC ANEMIA
Y. Ma, MD, PhD, Y. Okazaki, MD, PhD, M. Yeh, MS, K. Yeh, PhD and J. Glass, MD, Feist-Weiller Cancer Center, LSUHSC (Presented By: Y. Okazaki, MD, PhD)

03:30 pm
O-09: SUSTAINED HYDROGEN PEROXIDE INDUCES IRON UPTAKE BY TRANSFERRIN RECEPTOR-1 INDEPENDENT OF THE IRP/IRE NETWORK
F. Canonne-Hergaux, PhD, M. Roy, PhD, O. Thibaudeau, Technician, N. Riendeau, C. Bédard, P. Hélie and D. Malo, PhD, INSERM-CNRS (Presented By: F. Canonne-Hergaux, PhD)

02:00 pm - 02:15 pm
PS-02: SELECTIVE REDUCTION OF CEREBELLAR IRON ACCUMULATION IN FRIEDREICH’S ATAXIA ATTAINED BY A MODERATE DEFRIPRONE CHELATION TREATMENT
A. Munnich, MD PhD, N. Boddaert, MD, A. Roetig, PhD and I. Cabantchik, MD PhD, Hebrew University of Jerusalem (Presented By: I. Cabantchik, MD PhD)

02:15 pm - 02:30 pm
PS-03: ONCE-DAILY, ORAL CHELATION WITH DEFERASIROX (EXJADE®, ICL670) ROVIDES SUSTAINED PROTECTION FROM LABILE PLASMA IRON IN B-THALASSEMIA PATIENTS
S. Daar, A. Taher, A. Pathare, H. Nick, U. Krahn and D. Hadler, Novartis Pharmaceuticals (Presented By: H. Nick)

02:30 pm - 02:45 pm
PS-04: PK/PD PROFILES DURING DEFERASIROX (EXJADE®, ICL670) TREATMENT ARE SIMILAR IN JAPANESE AND CAUCASIAN PATIENTS WITH TRANSFUSIONAL IRON OVERLOAD
S. Iki, A. Urabe, T. Hata, K. Ohyashiki, S. Nakao, M. Takatoku, T. Ishikawa, J. Kato, Y. Tatsumi,H. Mori, H. Tanii, J. Taniguchi, M. Kondo, H. Schran and B. Rabault, NTT Kanto Medical Center (Presented By: A. Urabe)

02:45 pm - 03:00 pm
PS-05: IN VITRO PROTECTION BY SALICYLALDEHYDE ISONICOTINOYL HYDRAZONE (SIH) AGAINST ANTHRACYCLINE-INDUCED TOXICITY TO CARDIAC CELLS
T. Simunek, PhD, H. Kaiserova, MSc, M. Sterba, MSc, O. Popelova, MSc, M. Adamcova, PhD, P. Ponka, PhD and V. Gersl, PhD, Charles University in Prague, Faculty of Pharmacy, Department of Biochemical Sciences (Presented By: T. Simunek, PhD)

03:00 pm - 03:15 pm
PS-06: ENHANCED IRON UTILIZATION AND CORRECTION OF INFLAMMATION INDUCED ANEMIA BY ORALLY ACTIVE HIF PROLYL HYDROXYLASE INHIBITORS
I. Langsetmo, DVM; PhD, S. Todd, PhD, S. Oksana, PhD, S. Robert, PhD, G. David, MS, A. Michael, PhD, F. Lee A, PhD, L. Al, MD; PhD, L. David, PhD and S. Klaus, PhD, FibroGen, Inc. (Presented By: S. Klaus, PhD)

03:15 pm - 03:30 pm
PS-07: CURCUMIN, A CANCER CHEMOPREVENTIVE AGENT, IS A BIOLOGICALLY RELEVANT IRON CHELATOR
S. Torti, PhD, Y. Jiao, PhD, D. Kennedy, J. Cho, R. Planalp, PhD, F. Bou-Abdallah, PhD, N. Chasteen, PhD, J. Wilkinson IV, PhD, W. Wang and F. Torti, MD, Wake Forest University Health Sciences (Presented By: S. Torti, PhD)

03:30 pm - 03:45 pm
PS-08: GENE REGULATION THERAPY FOR SICKLE CELL DISEASE UTILIZING FERRITIN HEAVY CHAIN
R. Broyles, PhD, V. Belegu, PhD, A. Roth, BS, E. Clarkson, BS, K. Williamson, MS, C. Stewart, PhD, Q. Pye, MS, R. Floyd, PhD, K. Jani, PhD, M. Trudel, DSc, P. Santambrogio, PhD, S. Levi, PhD, P. Arosio, PhD and J. Cain, MD, University of Oklahoma Health Sciences Center (Presented By: R. Broyles, PhD)

03:45 pm - 04:00 pm
Closing Remarks
Jerry Kaplan, PhD

04:00 pm - 05:00 pm
EVENING SEMINAR: (Chair: Robert Crichton) co-sponsored by Chugai Pharmaceutical Co., Ltd.,

04:00 pm – 04:30 pm
ES-01: FRIEDREICH´S ATAXIA:CLINICAL PILOT TRIAL WITH RECOMBINANT HUMAN ERYTHROPOIETIN
B. Scheiber-Mojdehkar, PhD, S. Boesch, MD, S. Hering, MD, H. Goldenberg, Prof PhD, W. Poewe, MD and B. Sturm, PhD, Medical University of Vienna, Department of Medical Chemistry (Presented By: B. Scheiber-Mojdehkar, PhD)

01:30 pm - 02:45 pm
Concurrent Session 7: Erythropoiesis (Co-Chairs: Stefano Rivella, Osamu Nakajima)
Location: Hall II (Room C-1)

01:30 pm
O-25: IRON IS DIRECTLY TRANSFERRED FROM ENDOSOMES TO MITOCHONDRIA IN HEMOGLOBIN-SYNTHESIZING CELLS
A. Sheftel, PhD, T. Kahawita, BSc, A. Zhang, MD, C. Brown, PhD, O. Shirihai, MD, PhD and P. Ponka, MD, PhD, Lady Davis Instute, McGill University (Presented By: A. Sheftel, PhD)

01:45 pm
O-27: TRANSGENIC RESCUE OF ERYTHROID 5-AMINOLEVULINATE SYNTHASE-DEFICIENT MICE RESULTS IN THE FORMATION OF RING SIDEROBLASTS AND SIDEROCYTES
M. Schranzhofer, PhD, M. Schifrer, MS, P. Ponka, MD, PhD and E. Mullner, PhD, Lady Davis Institute for Medical Research, McGill University (Presented By: M. Schranzhofer, PhD)

02:00 pm
O-27: TRANSGENIC RESCUE OF ERYTHROID 5-AMINOLEVULINATE SYNTHASE-DEFICIENT MICE RESULTS IN THE FORMATION OF RING SIDEROBLASTS AND SIDEROCYTES
O. Nakajima, PhD, S. Okano, PhD, H. Harada, PhD,MD, T. Kusaka, PhD, X. Gao, PhD, T. Hosoya, PhD, N. Suzuki, PhD, S. Takahashi, PhD,MD and M. Yamamoto, PhD,MD, Research Laboratory for Molecular Genetics, Yamagata University (Presented By: O. Nakajima, PhD)

02:15 pm
O-28: ORGAN IRON DISTRIBUTION IN BETA-THALASSEMIA IS MEDIATED BY THE LEVEL OF ERYTHROPOIESIS AND IRON ABSORPTION RATHER THAT RED CELL APOPTOSIS OR HEMOLYSIS
S. Rivella, PhD, I. Libani, R. Schiro’, MD, T. Scholzen, PhD, P. Ramos, E. Guy, M. Kernbach, PhD, B. Baron-Luehr, PhD, L. Breda, PhD, M. Cappellini, MD, R. Grady, PhD, J. Gerdes, PhD and P. Giardina, MD, Weill Medical College of Cornell University (Presented By: S. Rivella, PhD)

2:30 pm
O-29: A PROTEOMIC ANALYSIS ON ERYTHROID ACTIVE PROTEIN EXPRESSION DURING DIFFERENTIATION OF FRIEND MURINE ERYTHROLEUKEMIA CELLS
C. Lok, PhD, Q. He, PhD and J. Chiu, PhD, The University of Hong Kong (Presented By: C. Lok, PhD)

01:30 pm - 02:45 pm
Concurrent Session 8: Hepcidin (Co-Chairs: Elizabeth Nemeth, Naohisa Tomosugi)
Location: Hall III (Room C-2)

01:30 pm
O-39: EVIDENCE THAT INHIBITION OF HEMOJUVELIN SHEDDING IN RESPONSE TO IRON IS MEDIATED THROUGH NEOGENIN
A. Zhang, S. Anderson, K. Meyers, C. Hernandez, R. Eisenstein and C. Enns, Oregon Health & Science University (Presented By: A. Zhang)

01:45 pm
O-40: THE ERYTHROPOIETIC REGULATOR OF HEPCIDIN CIRCULATES IN PLASMA
S. Rivera, MD, PhD, M. Pak, MD, Y. Desyatnikov, V. Gabayan and T. Ganz, PhD, MD, University of California, Los Angeles (Presented By: S. Rivera, MD, PhD)

02:00 pm
O-41: MOLECULAR MECHANISM OF HEPCIDIN-INDUCED DEGRADATION OF FERROPORTIN
D. Ward, PhD, I. De Domenico, PhD, C. Langelier, BS, M. Vaughn, BS, E. Nemeth, PhD, W. Sundquist, PhD, T. Ganz, MD, G. Musci, BS and J. Kaplan, PhD, University of Utah (Presented By: D. Ward, PhD)

02:15 pm
O-42: HEPCIDIN GENE EXPRESSION IS FURTHER SUPPRESSED IN HFE-/- MICE FOLLOWING CHRONIC ETHANOL CONSUMPTION.

L. Fletcher, PhD, M. Heritage, PhD, K. Bridle, PhD, T. Murphy, MSc, G. Anderson, PhD and D. Crawford, MD, FRACP, Dept Gastroenterology and Hepatology, Princess Alexandra Hospital (Presented By: L. Fletcher, PhD)

02:30 pm
O-43: ANTI-INTERLEUKIN 6 RECEPTOR ANTIBODY TOCILIZUMAB REDUCES THE LEVELS OF SERUM HEPCIDIN IN PATIENTS WITH MULTICENTRIC CASTLEMAN’S DISEASE
H. Kawabata, MD, N. Tomosugi, MD, J. Kanda, MD, Y. Tanaka, MD, N. Kadowaki, MD, T. Ichinohe, MD, T. Ishikawa, MD and T. Uchiyama, MD, Department of Hematology and Oncology,Graduate School of Medicine, Kyoto University (Presented By: H. Kawabata, MD)

02:45 pm - 04:00 pm
Concurrent Session 9: Brain Iron Degeneration (CNS) (Chairs: Marco T. Nunez, Kazuhisa Taketa)
Location: Hall II (Room C-1)

02:45 pm
O-30: REGIONAL AND CELLULAR DISTRIBUTION OF MITOCHONDRIAL FERRITIN IN THE MOUSE BRAIN
J. Connor, PhD, A. (Snyder) Ill, G. Baisiotto, P. Arosio and S. Levi, Pennsylvania State University College of Medicine (Presented By: J. Connor, PhD)

03:00 pm
O-31: DOWN REGULATION OF FERROPORTIN IN ALZHEIMER’S AND PARKINSON’S DISEASE AND THE AGEING BRAIN: IMPLICATIONS FOR AXONAL IRON TRANSPORT AND DEGRADATION BY AUTOPHAGY OR PROTEOSOMAL PATHWAYS
J. Kwok, PhD, J. Zhao, PhD, L. Rodrick, PhD, A. Bomford, MBBS, FRCP and R. Raha-Chowdhury, PhD, UNIVERSITY OF CAMBRIDGE (Presented By: R. Raha-Chowdhury, PhD)

03:15 pm
O-32: UP-REGULATION OF LON PROTEASE IS ASSOCIATED WITH THE DECREASE IN MITOCHONDRIAL FE-S PROTEIN LEVELS IN A MOUSE MODEL OF FRIEDREICH ATAXIA

C. Bouton, PhD, B. Guillon, Engineer, A. Bulteau, PhD, H. Puccio, PhD and J. Drapier, PhD, Institut de Chimie des Substances Naturelles-CNRS (Presented By: C. Bouton, PhD)

03:30 pm
O-33: THE FUNCTIONAL POLYMORPHISM OF THE HEMOGLOBIN-BINDING PROTEIN HAPTOGLOBIN INFLUENCES SUSCEPTIBILITY TO IDIOPATHIC PARKINSON’S DISEASE
S. Sadrzadeh, PhD, P. Costa-Mallen, PhD, A. Zabeti, MD, M. Edenfield, BS, P. Swanson, MD, W.Longstreth, MD, G. Franklin, MD, T. Smith-Weller, COHN and H. Checkoway, PhD, University of Washington (Presented By: S. Sadrzadeh, PhD)

03:45 pm
O-34: HEPATIC IRON OVERLOAD ASSOCIATED WITH A DECREASED SERUM CERULOPLASMIN LEVEL IN A NOVEL CLINICAL TYPE OF A ACERULOPLASMINEMIA
S. Kono, MD, H. Miyajima, MD, H. Suzuki, MD, K. Takahashi, MD, Y. Takahashi, MD, K. Shirakawa, MD, Y. Murakawa, MD and S. Yamaguchi, MD, First Department of Medicine, Hamamatsu University School of Medicine (Presented By: S. Kono, MD)

02:45 pm - 04:00 pm
Concurrent Session 10: Regulatory System of Iron Metabolism (Co-Chairs: Hiromi Gunshin, Takeshi Nakanishi)
Location: Hall III (Room C-2)

02:45 pm
O-44: WILD-TYPE FERROPORTIN IS NOT IMPEDED IN MATURATION, CELL SURFACE EXPRESSION OR IRON EXPORT FUNCTION BY MUTANT FERROPORTIN, AND BIO-LUMINESCENCE RESONANCE ENERGY TRANSFER (BRET) EXPERIMENTS INDICATE MONOMERIC FORM IN CELL MEMBRANES
L. Schimanksi, BSc, MSc, H. Drakemth, BA, PhD, C. Talbot, BA, K. Horne, BA, J. James, BSc, E. Sweetland, BSc, MSc, J. Bastin, BSc, PhD, D. Cowley, D. Simon, PhD and A. Townsend, PhD, MBBS, Oxford University (Presented by: L. Schimanski, BSc, MSc)

03:00 pm
O-45: THE FLATIRON MUTATION IN MOUSE FERROPORTIN ACTS AS A DOMINANT NEGATIVE TO CAUSE HEMOCHROMATOSIS TYPE IV
I. De Domenico, PhD, I. Zohn, PhD, A. Pollack, BS, D. Ward, PhD, J. Goodman, BS, X. Liang, BS, A. Sanchez, BS, L. Niswander, PhD and J. Kaplan, PhD, University of Utah (Presented By: I. De Domenico, PhD)

03:15 pm
O-46: IDENTIFICATION OF NEW LIGANDS FOR THE HAEMOCHROMATOSIS PROTEIN HFE
H. Drakesmith, BA, PhD, E. Sweetland, MSc, D. Li, PhD, L. Schimanski, MSc, J. Bastin, PhD, D. Cowley, X. Xu, PhD and A. Townsend, PhD, MBBsc, Molecular Immunology Group, WeatherallInstitute of Molecular Medicine (Presented By: H. Drakesmith, BA, PhD)

03:30 pm
O-47: DISEASE CAUSING MUTATIONS OF TRANSFERRIN RECEPTOR 2 CAUSE ITS INTRACELLULAR RETENTION
V. Subramaniam, M Sc, PhD, L. Summerville, BSc, GradDip and D. Wallace, BSc (Hons), PhD, Queensland Institute of Medical Research (Presented By: V. Subramaniam, M Sc, PhD)

03:45 pm
O-48: THE BINDING OF TRANSFERRIN RECEPTOR 2 TO THE HEREDITARY HEMOCHROMATOSIS PROTEIN, HFE, ALTERS ITS TRAFFICKING AND STABILITY
C. Enns, PhD, M. Chloupkova, J. Chen and J. Gao, Oregon Health & Science University (Presented By: C. Enns, PhD)

Miniature boats were being “sailed” off of the esplanade.

Mom’s favorite flowers of the day.

Family pic across from the Japanese Garden.

Ella and Mommy by the waterfall.

Ella and Daddy at the Japanese Garden entrance.

Preparing wedding flowers!!! How beautiful.

Miles having fun falling down in the rose garden.

Mommy and Miles.

Mom gets a hug from Miles as she tries to pose with Ella.

On January 17, testifying before the Senate Committee on the Judiciary on the subject of anticompetitive patent settlements in the U.S. pharmaceutical industry, FTC Commissioner Jon Leibowitz said that recent court cases have made it more difficult to bring antitrust cases to stop exclusion payment settlements between brand manufacturers and their generic competitors, and that “the impact of the court rulings is becoming evident in the marketplace.

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